動物生産學

姓名

全林虎

性别

男

民族

朝鮮族

學位

博士

職稱

教授

職務

電話

18243301765

郵箱

lhquan@ybu.edu.cn

個人經曆

學習經曆

(1) 1999-09至2003-07, 延邊大學, 農學, 學士

(2) 2006-09至2008-07, 韓國慶熙大學, 中藥材料加工, 碩士

(3) 2009-03至2012-02, 韓國慶熙大學, 中藥材料加工, 博士

工作經曆

(1) 2014-08至2017-08,延邊大學,長白山生物資源與功能分子教育部重點實驗室, 講師

(2) 2017-09 至 2020-06,延邊大學,長白山生物資源與功能分子教育部重點實驗室, 教授

(3) 2020-07 至 今,延邊大學,藥學院,教授

承擔主要課程

本科生課程：化學生物學，藥學前言講座

研究生課程：體内藥物分析，藥理學進展

研究方向

腸道菌群的紊亂和肥胖以及代謝綜合征有着密切的關系。腸道菌群可以作為防治肥胖的新的靶目标，通過益生元、益生菌來糾正腸道菌群紊亂，能夠改善代謝綜合征。課題組主要以腸道菌群為靶點，采用微生物組學和代謝組學，系統分析中藥引起腸道菌群組成、功能基因、代謝産物的改變，通過機體-細胞-分子等多層次研究，明确中藥、代謝産物、腸道菌群與疾病之間複雜的協同作用分子機制，建立利用腸道菌群評估植物藥療效技術方法，為中藥對疾病的預防治療提供理論依據，為以腸道菌群為靶點的新型藥物的研發提供科學支撐。

論文著作、科研成果及榮譽

主持完成了校級科研項目，州、省級科研項目多項和國家自然基金項目2項。發表論文30餘篇。

1、承擔科研項目情況

(1) 國家自然科學基金委員會, 地區科學基金項目, 32260026, 草苁蓉介導的腸道Lactobacillus reuteri菌通過長鍊脂肪酸調控糖脂代謝改善2型糖尿病的作用機制，2023-01-01 至 2026-12-31, 33萬元, 在研, 主持

(2) 國家自然科學基金委員會, 地區科學基金項目, 81660643, 腸道菌群多樣性與人參皂苷代謝差異相關性及其作用機制研究, 2017-01-01 至 2020-12-31, 39萬元, 結題, 主持

(3) 吉林省委,吉林省“長白山人才工程青年拔尖人才”, 000007, 腸道菌群在代謝性疾病中的應用, 2022-01 至 2026-12, 25萬元, 在研, 主持

(4) 吉林省科技廳, 吉林省自然科學基金, 20210101206JC, 紅景天提取物介導的腸道菌群調控脂代謝的作用, 2022-01 至 2024-12, 10萬元, 在研, 主持

(5) 吉林省教育廳, 吉林省教育廳科學技術研究規劃項目, JJKH20210586KJ, 人參皂苷CK激活棕色脂肪改善肥胖的作用機制研究, 2021-01 至 2022-12, 2.5萬元, 結題, 主持

(6) 吉林省人力資源和社會保障廳, 2020年度吉林省創新創業人才, 2020022, 人參調控糖脂代謝的研究與應用, 2020-06 至 2021-12, 20萬元, 結題, 主持

(7) 中國博士後面上基金項目，2015M571376，乳酸菌中轉化稀有人參皂苷C-K糖苷酶基因的篩選，2015-05至2016-12，5萬元，結題，主持

(8) 吉林省擇優資助博士後科研項目，014000008，生物轉化稀有人參皂苷compound K關鍵酶基因的克隆及應用，2015-03至2016-12，3萬元，結題，主持

2、代表性論文（2017至今SCI一區/二區）

(1) Lin-Hu Quan; Zhang Chuanhai; Dong Meng; Jiang Jun; Xu Hongde; Yan Chunlong; Liu Xiaomeng; Zhou Huiqiao; Zhang Hanlin; Chen Li; Zhong Fei-Liang; Luo Zhao-Bo; Lam Sin-Man; Shui Guanghou; Li Donghao; Jin Wanzhu; Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation. GUT, 2020, 69(7): 1239-1247. (SCI一區TOP期刊，ESI前1%高被引論文，影響因子31.79)

(2) Zhao-Bo Luo; Shengzhong Han; Xi-Jun Yin; Hongye Liu; Junxia Wang; Meifu Xuan; Chunyun Hao; Danqi Wang; Yize Liu; Shuangyan Chang; Dongxu Li; Kai Gao; Huiling Li; Biaohu Quan; Lin-Hu Quan*; Jin-Dan Kang*; Fecal transplant from myostatin deletion pigs positively impacts the gut-muscle axis. eLife, 2023, DOI: https://doi.org/10.7554/eLife.81858. (SCI一區TOP期刊，自然指數期刊，影響因子8.7)

(3) Rongcai Ye; Chunlong Yan; Huiqiao Zhou; Chuanhai Zhang; Yuanyuan Huang; Meng Dong; Hanlin Zhang; Jun Lin; Xiaoxiao Jiang; Shouli Yuan; Li Chen; Rui Jiang; Ziyu Cheng; Kexin Zheng; Anni Yu; Qiaoli Zhang; Lin-Hu Quan*; Wanzhu Jin*; Brown adipose tissue activation with ginsenoside compound K ameliorates polycystic ovary syndrome, British Journal of Pharmacology. 2022, 179(18):4563-4574. (SCI一區TOP期刊，影響因子9.47)

(4) Yize Liu; Zheng-Yun Jin; c Jun-Xia Wang; Danqi Wang; Hongye Liu; Dongxu Li; Jun Zhu; Zhao-Bo Luo; Sheng-Zhong Han; Shuang-Yan Chang; Liu-Hui Yang; Jin-Dan Kang*; Lin-Hu Quan*; Ginsenoside Rg1 activates brown adipose tissue tocounteract obesity in high-fat diet-fed mice by regulating gut microbes and bile acid composition. Food & Function, 2023, DOI: 10.1039/d2fo03142f. (SCI一區TOP期刊，影響因子6.317)

(5) Sheng-Zhong Han; Kai Gao; Shuang-Yan Chang; Hak-Myong Choe; Hyo-Jin Paek; Biao-Hu Quan; Xin-Yue Liu; Liu-Hui Yang; Si-Tong Lv; Xi-Jun Yin; Lin-Hu Quan*; Jin-Dan Kang*; miR-455-3p Is Negatively Regulated by Myostatin in Skeletal Muscle and Promotes Myoblast Differentiation. Journal of Agricultural and Food Chemistry, 2022, 70(33):10121-10133. (SCI一區TOP期刊，影響因子5.89)

(6) Wei-Wei Dong; Fang-Ling Xuan; Fei-Liang Zhong; Jun Jiang; Songquan Wu; Donghao Li; Lin-Hu Quan*; Comparative Analysis of the Rats' Gut Microbiota Composition in Animals with Different Ginsenosides Metabolizing Activity. Journal of Agricultural and Food Chemistry, 2017, 65(2): 327-337. (SCI一區TOP期刊，影響因子5.89)

(7) Wei-Wei Dong; Jinhua Zhao; Fei-Liang Zhong; Wen-Jing Zhu; Jun Jiang; Songquan Wu; Deok-Chun Yang; Donghao Li; Lin-Hu Quan*; Biotransformation of Panax ginseng extract by rat intestinal microflora: identification and quantification of metabolites using liquid chromatography-tandem mass spectrometryx, Journal of Ginseng Research, 2017, 41(4):540-547. (SCI一區TOP期刊，影響因子5.73)

(8) Xiong-Zhe Han, Rui Ma, Qi Chen, Xin Jin, Yuan-Zhe Jin, Ren-Bo An, Xuan-Mei Piao, Mei-Lan Lian, Lin-Hu Quan*, Jun Jiang; Anti-inflammatory action of Athyrium multidentatum extract suppresses the LPS-induced TLR4 signaling pathway. Journal of Ethnopharmacology, 2018, 217:220-227. (SCI一區TOP期刊，影響因子5.19)

(9) Hongye Liu; Zhi-Yong An; Zhou-Yan Li; Liu-Hui Yang; Xiu-Li Zhang; Yan-Tong Lv; Xi-Jun Yin; Lin-Hu Quan*; Jin-Dan Kang*; The ginsenoside Rh2 protects porcine oocytes against aging and oxidative stress by regulating SIRT1 expression and mitochondrial activity. Theriogenology, 2023, 200:125-135. (SCI一區TOP期刊，影響因子2.92)

(10) Danqi Wang; Jun-Xia Wang; Chunri Yan; Yize Liu; Hongye Liu; Dongxu Li; Jun Zhu; Zhao-Bo Luo; Sheng-Zhong Han; Zheng-Yun Jin; Shuang-Yan Chang; Liu-Hui Yang; Jin-Dan Kang*; Lin-Hu Quan*; Gastrodia elata Blume extract improves high-fat diet-induced type 2 diabetes by regulating gut microbiota and bile acid profile. Frontiers in Microbiology, 2022, 13:1091712. (SCI二區TOP期刊，影響因子6.06)

(11) Shuang-Yan Chang; Sheng-Zhong Han; Hak-Myong Choe; Kai Gao; Zheng-Yun Jin; Xin-Yue Liu; Liu-Hui Yang; Si-Tong Lv; Xi-Jun Yin; Lin-Hu Quan*; Jin-Dan Kang*; miR-320 regulates myogenesis by targeting growth factor receptor-bound protein-2 and ameliorates myotubes atrophy. Int J Biochem Cell Biol, 2022, 147:106212. (SCI二區，影響因子5.65)

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